Letter to the Editor: Authors’ Response

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141389/1/jper1035.pd

Clinical Text Summarization: Adapting Large Language Models Can Outperform Human Experts

Sifting through vast textual data and summarizing key information imposes a substantial burden on how clinicians allocate their time. Although large language models (LLMs) have shown immense promise in natural language processing (NLP) tasks, their efficacy across diverse clinical summarization tasks has not yet been rigorously examined. In this work, we employ domain adaptation methods on eight LLMs, spanning six datasets and four distinct summarization tasks: radiology reports, patient questions, progress notes, and doctor-patient dialogue. Our thorough quantitative assessment reveals trade-offs between models and adaptation methods in addition to instances where recent advances in LLMs may not lead to improved results. Further, in a clinical reader study with six physicians, we depict that summaries from the best adapted LLM are preferable to human summaries in terms of completeness and correctness. Our ensuing qualitative analysis delineates mutual challenges faced by both LLMs and human experts. Lastly, we correlate traditional quantitative NLP metrics with reader study scores to enhance our understanding of how these metrics align with physician preferences. Our research marks the first evidence of LLMs outperforming human experts in clinical text summarization across multiple tasks. This implies that integrating LLMs into clinical workflows could alleviate documentation burden, empowering clinicians to focus more on personalized patient care and other irreplaceable human aspects of medicine.Comment: 23 pages, 22 figure

Effect of Microthreads and Platform Switching on Crestal Bone Stress Levels: A Finite Element Analysis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142288/1/jper2166.pd

The Gemini Planet Imager Exoplanet Survey: Giant Planet and Brown Dwarf Demographics From 10-100 AU

We present a statistical analysis of the first 300 stars observed by the Gemini Planet Imager Exoplanet Survey (GPIES). This subsample includes six detected planets and three brown dwarfs; from these detections and our contrast curves we infer the underlying distributions of substellar companions with respect to their mass, semi-major axis, and host stellar mass. We uncover a strong correlation between planet occurrence rate and host star mass, with stars M $>$ 1.5 $M_\odot$ more likely to host planets with masses between 2-13 M$_{\rm Jup}$ and semi-major axes of 3-100 au at 99.92% confidence. We fit a double power-law model in planet mass (m) and semi-major axis (a) for planet populations around high-mass stars (M $>$ 1.5M$_\odot$) of the form $\frac{d^2 N}{dm da} \propto m^\alpha a^\beta$, finding $\alpha$ = -2.4 $\pm$ 0.8 and $\beta$ = -2.0 $\pm$ 0.5, and an integrated occurrence rate of $9^{+5}_{-4}$% between 5-13 M$_{\rm Jup}$ and 10-100 au. A significantly lower occurrence rate is obtained for brown dwarfs around all stars, with 0.8$^{+0.8}_{-0.5}$% of stars hosting a brown dwarf companion between 13-80 M$_{\rm Jup}$ and 10-100 au. Brown dwarfs also appear to be distributed differently in mass and semi-major axis compared to giant planets; whereas giant planets follow a bottom-heavy mass distribution and favor smaller semi-major axes, brown dwarfs exhibit just the opposite behaviors. Comparing to studies of short-period giant planets from the RV method, our results are consistent with a peak in occurrence of giant planets between ~1-10 au. We discuss how these trends, including the preference of giant planets for high-mass host stars, point to formation of giant planets by core/pebble accretion, and formation of brown dwarfs by gravitational instability.Comment: 52 pages, 18 figures. AJ in pres

Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism

A comprehensive genome-scale metabolic network of Chlamydomonas reinhardtii, including a detailed account of light-driven metabolism, is reconstructed and validated. The model provides a new resource for research of C. reinhardtii metabolism and in algal biotechnology

An Updated Visual Orbit of the Directly Imaged Exoplanet 51 Eridani b and Prospects for a Dynamical Mass Measurement with \u3ci\u3eGaia\u3c/i\u3e

We present a revision to the visual orbit of the young, directly imaged exoplanet 51 Eridani b using four years of observations with the Gemini Planet Imager. The relative astrometry is consistent with an eccentric (e= 0.53-0.13+0.09) orbit at an intermediate inclination (i= 13611+10°), although circular orbits cannot be excluded due to the complex shape of the multidimensional posterior distribution. We find a semimajor axis of 11.1-1.3+4.2 au and a period of 28.1-4.9+17.2 yr, assuming a mass of 1.75 M· for the host star. We find consistent values with a recent analysis of VLT/SPHERE data covering a similar baseline. We investigate the potential of using the absolute astrometry of the host star to obtain a dynamical mass constraint for the planet. The astrometric acceleration of 51 Eri derived from a comparison of the Hipparcos and Gaia catalogs was found to be inconsistent at the 2ω-3ω level with the predicted reflex motion induced by the orbiting planet. Potential sources of this inconsistency include a combination of random and systematic errors between the two astrometric catalogs and the signature of an additional companion within the system interior to current detection limits. We also explored the potential of using Gaia astrometry alone for a dynamical mass measurement of the planet by simulating Gaia measurements of the motion of the photocenter of the system over the course of the extended 8 yr mission. We find that such a measurement is only possible (\u3e98% probability) given the most optimistic predictions for the Gaia scan astrometric uncertainties for bright stars and a high mass for the planet (≳3.6 MJup)

Detection of a Low-Mass Stellar Companion to the Accelerating A2IV Star HR 1645

The ∼500 Myr A2IV star HR 1645 has one of the most significant low-amplitude accelerations of nearby early-type stars measured from a comparison of the Hipparcos and Gaia astrometric catalogs. This signal is consistent with either a stellar companion with a moderate mass ratio (q ∼ 0.5) on a short period (P \u3c 1 yr), or a substellar companion at a separation wide enough to be resolved with ground-based high-contrast imaging instruments; long-period equal-mass ratio stellar companions that are also consistent with the measured acceleration are excluded with previous imaging observations. The small but significant amplitude of the acceleration made HR 1645 a promising candidate for targeted searches for brown dwarf and planetary-mass companions around nearby, young stars. In this paper we explore the origin of the astrometric acceleration by modeling the signal induced by a wide-orbit M8 companion discovered with the Gemini Planet Imager, as well as the effects of an inner short-period spectroscopic companion discovered a century ago but not since followed up. We present the first constraints on the orbit of the inner companion, and demonstrate that it is a plausible cause of the astrometric acceleration. This result demonstrates the importance of vetting of targets with measured astrometric acceleration for short-period stellar companions prior to conducting targeted direct imaging surveys for wide-orbit substellar companions

First Resolved Scattered-Light Images of Four Debris Disks in Scorpius-Centaurus with the Gemini Planet Imager

We present the first spatially resolved scattered-light images of four debris disks around members of the Scorpius-Centaurus (Sco-Cen) OB association with high-contrast imaging and polarimetry using the Gemini Planet Imager (GPI). All four disks are resolved for the first time in polarized light, and one disk is also detected in total intensity. The three disks imaged around HD 111161, HD 143675, and HD 145560 are symmetric in both morphology and brightness distribution. The three systems span a range of inclinations and radial extents. The disk imaged around HD 98363 shows indications of asymmetries in morphology and brightness distribution, with some structural similarities to the HD 106906 planet-disk system. Uniquely, HD 98363 has a wide comoving stellar companion, Wray 15-788, with a recently resolved disk with very different morphological properties. HD 98363 A/B is the first binary debris disk system with two spatially resolved disks. All four targets have been observed with ALMA, and their continuum fluxes range from one nondetection to one of the brightest disks in the region. With the new results, a total of 15 A/F stars in Sco-Cen have resolved scattered-light debris disks, and approximately half of these systems exhibit some form of asymmetry. Combining the GPI disk structure results with information from the literature on millimeter fluxes and imaged planets reveals a diversity of disk properties in this young population. Overall, the four newly resolved disks contribute to the census of disk structures measured around A/F stars at this important stage in the development of planetary systems

HD 165054: An Astrometric Calibration Field for High-Contrast Imagers in Baade\u27s Window

We present a study of the HD 165054 astrometric calibration field that has been periodically observed with the Gemini Planet Imager (GPI). HD 165054 is a bright star within Baade\u27s Window, a region of the galactic plane with relatively low extinction from interstellar dust. HD 165054 was selected as a calibrator target due to the high number density of stars within this region (?3 stars per square arcsecond with H \u3c 22), necessary because of the small field of view of the GPI. Using nine epochs spanning over five years, we have fit a standard five-parameter astrometric model to the astrometry of seven background stars within close proximity to HD 165054 (? \u3c 2?). We achieved a proper motion precision of ?0.3 mas yr-1 and constrained the parallax of each star to be ?1 mas. Our measured proper motions and parallax limits are consistent with the background stars being a part of the galactic bulge. Using these measurements, we find no evidence of any systematic trend of either the plate scale or the north angle offset of GPI between 2014 and 2019. We compared our model describing the motions of the seven background stars to observations of the same field in 2014 and 2018 obtained with Keck/NIRC2, an instrument with excellent astrometric calibration. We find that the predicted position of the background sources is consistent with that measured by NIRC2, within the uncertainties of the calibration of the two instruments. In the future, we will use this field as a standard astrometric calibrator for the upgrade of GPI and potentially for other high-contrast imagers